36 Hours in Cambridge, Mass.

Founded in 1630, the venerable college town of Cambridge has long been one of the nation’s intellectual centers. Anchored to the banks of the Charles River by both Harvard University and the Massachusetts Institute of Technology, the city blends its storied past and erudite character with a rich serving of arts and culture. Today, the stamp of gentrification on Harvard Square and the gleaming biotech development flanking M.I.T., a.k.a. “Genetown,” make it harder to tune into Cambridge’s legendary countercultural vibe of used bookstores and punk rockers. Still, the outward-looking citizens, known as Cantabrigians, keep finding ways to express their funky, geeky flair, be it via political protests, copious bike lanes or science-driven cuisine and mixology.